Riebel and Hesse were the earliest authors to draw attention to the aggravation of acne by isoniazid. In another study, five of seven patients were found to be slow inactivators of isoniazid. These five patients were aged between 32 and 48 years and the other two were younger. The clinical pictures consisted predominantly of blackheads and inflammatory papules.. An acneiform eruption, consisting of papules on the face, back and chest, appears to be a fairly common problem in Zambian men treated... read more
